December 1, 2000British Journal of PharmacologyOpen Access

Mechanical stretch reveals different components of endothelial‐mediated vascular tone in rat aortic strips

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Population

Isolated rat aortic helical strips (endothelium-preserved)

Comparison

Mechanical stretch with acetylcholine… vs Different levels of resting tension and…

Design

Preclinical

Authors

SFSergio Franchi‐MicheliUniversity of Florence PFPaola FailliUniversity of Florence LMLuca MazzettiAzienda Ospedaliero-Universitaria Careggi

Discussion

Member takes

Implication

Rat aortic data should not guide clinical vascular practice; leaves open stretch effects on human endothelial NO pathways.

Structured PICO

Population

Isolated rat aortic helical strips (endothelium-preserved)

Intervention

Mechanical stretch (resting tension set at 0.7 g, 1.2 g, or 2.5 g) with acetylcholine administration after precontraction

Comparator

Different levels of resting tension and presence/absence of various inhibitors (NOS, COX, lipoxygenase)

Outcome

Isometric contraction/relaxation (vascular tone)surrogate

Mechanical stretch alters the pathways of endothelial-mediated vascular tone regulation in rat aortas, shifting from stored NO and COX metabolites at low stretch to de novo NO synthesis at high stretch.

Cite This Study

Franchi‐Micheli et al. (2000) studied this question.

synapsesocial.com/papers/6a8857df8e586ad1c8a55231 https://doi.org/10.1038/sj.bjp.0703707

View Full Paper

Ask AI

Bookmark

Mechanical stretch reveals different components of endothelial‐mediated vascular tone in rat aortic strips

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanical stretch reveals different components of endothelial‐mediated vascular tone in rat aortic strips

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider