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July 1, 1993Fundamental and Clinical Pharmacology

Influence of the endothelium on Ca2+dependency of angiotensin II‐induced contractions of rat aortic rings

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Population

Rat aortic rings with and without endothelium

Comparison

Angiotensin II in the presence of Ca2+ entry… vs Responses in rings with vs without endothelium…

Design

Preclinical

Authors

PHPNM van HeiningenPZPA van Zwieten

Discussion

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Overview

Highlights nifedipine-insensitive endothelial calcium pathways in rat aorta; hypothesis-generating for vascular pharmacology without human data.

Structured PICO

P
Population
Rat aortic rings with and without endothelium
I
Intervention
Angiotensin II in the presence of Ca2+ entry blockers (nifedipine, CoCl2) or Ca2+-free solution
C
Comparator
Responses in rings with vs without endothelium, and with vs without Ca2+ entry blockers
O
Outcome
Angiotensin II-induced contractions (expressed as percentage of maximal contraction to noradrenaline)surrogate

Endothelium-mediated relaxation in rat aortic rings depends on calcium influx through channels insensitive to organic calcium entry blockers like nifedipine.

Cite This Study

Heiningen et al. (1993) studied this question.

synapsesocial.com/papers/6a8b1fa0c12eaf65c8b1fad4https://doi.org/10.1111/j.1472-8206.1993.tb00236.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcium- and endothelial-mediated vascular smooth muscle relaxation in rabbit aorta.1982 · 203 citations
  2. 2Calcium Channel Activation Does Not Increase Release of Endothelial-Derived Relaxant Factors (EDRF) in Rat Aorta Although Tonic Release of EDRF May Modulate Calcium Channel Activity in Smooth Muscle1986 · 53 citations
  3. 3Pre- and Postsynaptic Effects of Angiotensins in the Femoral Artery of Spontaneously Hypertensive and Wistar-Kyoto Rats2008 · 11 citations
  4. 4Mechanism of Calcium Activation in Vascular Smooth Muscle1987 · 44 citations
  5. 5Influence of calcium-entry blockade on vasoconstrictor responses in feline mesenteric vascular bed.1987 · 13 citations