November 1, 1986Journal of Cardiovascular Pharmacology

Calcium Channel Activation Does Not Increase Release of Endothelial-Derived Relaxant Factors (EDRF) in Rat Aorta Although Tonic Release of EDRF May Modulate Calcium Channel Activity in Smooth Muscle

View Full Paper

Ask AI

Bookmark

Why the study?

Does calcium channel activation increase the release of EDRF in rat aorta?

Population

Rat aorta preparations

Comparison

Calcium channel activation by K+ or Bay K 8644 vs Rat aorta preparations stripped of endothelium…

Design

Preclinical

Authors

MSMichael SpeddingTa Solutions (China)VSValérie B. SchiniBaylor College of Medicine PSPhilippe SchoeffterNovartis (Switzerland)

Discussion

Member takes

Implication

Calcium channel activation does not increase EDRF release in rat aorta; leaves open whether tonic EDRF modulates calcium channel sensitivity in vivo.

Structured PICO

Does calcium channel activation increase the release of EDRF in rat aorta?

Population

Rat aorta preparations

Intervention

Calcium channel activation by K+ or Bay K 8644 (0.1-100 nM, 10 nM-1 microM)

Comparator

Rat aorta preparations stripped of endothelium; different calcium antagonists (nifedipine, verapamil, cinnarizine)

Outcome

Release of endothelium-derived relaxant factor (EDRF) measured by relaxation of partially contracted aorta or cGMP contentsurrogate

Calcium channel activation does not increase EDRF release in rat aorta, but tonic EDRF release may modulate smooth muscle calcium channel activity and sensitivity to calcium antagonists.

Cite This Study

Spedding et al. (1986) studied this question.

synapsesocial.com/papers/6a8b1f5ad5d4290f64f461c2 https://doi.org/10.1097/00005344-198611000-00006

View Full Paper

Ask AI

Bookmark

Implication

Calcium channel activation does not increase EDRF release in rat aorta; leaves open whether tonic EDRF modulates calcium channel sensitivity in vivo.

Calcium Channel Activation Does Not Increase Release of Endothelial-Derived Relaxant Factors (EDRF) in Rat Aorta Although Tonic Release of EDRF May Modulate Calcium Channel Activity in Smooth Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Calcium Channel Activation Does Not Increase Release of Endothelial-Derived Relaxant Factors (EDRF) in Rat Aorta Although Tonic Release of EDRF May Modulate Calcium Channel Activity in Smooth Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider