Population
Segments of rabbit abdominal aorta
Comparison
Blockade of KCa channels and KATP channels under… vs Unblocked state or different flow/agonist…
Design
Preclinical
Authors
Loading...
Distinguishes K+ channel roles in pulsatile vs steady shear in rabbit aorta; leaves open translation to human endothelial function.
A spectrum of KCa channel subtypes mediates endothelial transduction of pulsatile flow, while KATP channels are involved in time-averaged shear stress transduction, but agonist-stimulated relaxation is independent of K+ channel activation in rabbit aorta.
Hutcheson et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: