November 12, 1989Fundamental and Clinical Pharmacology

(‐)‐bay K 8644 Liberates a Contractant Factor From the Endothelium of the Rat Aorta

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Population

Rat isolated aortic ring preparations

Comparison

-Bay k 8644 in a potassium-free medium vs Tissues deprived of a functional endothelium…

Design

Preclinical

Authors

KLKim LawsonQueen Charlotte's and Chelsea Hospital ICIcilio CaveroTotal (France)

Discussion

Member takes

Implication

Endothelium-dependent contraction via COX products in rat aorta is hypothesis-generating; leaves open relevance to human vascular tone or therapy.

Structured PICO

Population

Rat isolated aortic ring preparations

Intervention

(-)-Bay k 8644 (0.01-3 microM) in a potassium-free medium

Comparator

Tissues deprived of a functional endothelium, and preparations treated with various inhibitors (quinacrine, indomethacin, diclofenac, nordihydroguaiaretic acid, dazoxiben)

Outcome

Contractile responsesurrogate

(-)-Bay k 8644 induces contraction in rat aorta by releasing an endothelium-derived contractant factor, likely a cyclo-oxygenase product.

Cite This Study

Lawson et al. (1989) studied this question.

synapsesocial.com/papers/6a8b1fa0c12eaf65c8b1fad6 https://doi.org/10.1111/j.1472-8206.1989.tb00469.x

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Implication

Endothelium-dependent contraction via COX products in rat aorta is hypothesis-generating; leaves open relevance to human vascular tone or therapy.

(‐)‐bay K 8644 Liberates a Contractant Factor From the Endothelium of the Rat Aorta

Discussion

Member takes

Implication

Structured PICO

Cite This Study

(‐)‐bay K 8644 Liberates a Contractant Factor From the Endothelium of the Rat Aorta

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider