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November 8, 2006AJP Renal Physiology

Effects of inhibition of the Na+/K+/2Cl− cotransporter on myogenic and angiotensin II responses of the rat afferent arteriole

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Population

in vitro perfused hydronephrotic rat kidney model (afferent arteriole)

Design

Preclinical

Authors

XWXuemei WangJBJennifer BreaksKLKathy Loutzenhiser

Discussion

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Overview

NKCC1 inhibition may modulate renal microvascular tone; hypothesis-generating for diuretic mechanisms beyond natriuresis and requires in vivo validation.

Structured PICO

P
Population
in vitro perfused hydronephrotic rat kidney model (afferent arteriole)
I
Intervention
NKCC inhibitors (furosemide and bumetanide)
O
Outcome
vasoconstrictor responses (myogenic and ANG II-induced)surrogate

NKCC modulation alters myogenic responses in the renal microvasculature by a mechanism independent of tubuloglomerular feedback, suggesting a role for NKCC1 in vasomotor function regulation.

Cite This Study

Wang et al. (2006) studied this question.

synapsesocial.com/papers/6a70a14b5671bbf00bc2bd85https://doi.org/10.1152/ajprenal.00343.2006
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