Population
NKCC1-deficient and wild-type mice, as well as primary cultures of single juxtaglomerular granular cells…
Comparison
Acute administration of furosemide. vs Baseline and wild-type mice.
Design
Preclinical
Authors
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NKCC1 may tonically suppress renin; extends mechanistic understanding in mice but leaves open human relevance and should not change practice.
This preclinical study demonstrates that functional NKCC1 suppresses basal renin release and that loop diuretics like furosemide directly stimulate renin secretion by inhibiting NKCC1 in juxtaglomerular cells.
Castrop et al. (2005) studied this question.
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