What question did this study set out to answer?

To assess how chronic furosemide treatment and oral sodium loading influence glomerular filtration rate, renal sodium excretion, and segmental nephron Na+-K+-ATPase activity.

May 1, 1987AJP Renal Physiology

Enhanced glomerular filtration and Na+-K+-ATPase with furosemide administration

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Authors

PSPeter ScherzerUniversité du Québec à Montréal HWHanna WaldIsrael Institute for Biological Research MPM. M. PopovtzerHadassah Academic College

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Implication

Animal experiment reveals enhanced filtration and distal tubular Na+-K+-ATPase activity following chronic furosemide administration in rats, indicating compensatory distal sodium handling.

Key Points

To assess how chronic furosemide treatment and oral sodium loading influence glomerular filtration rate, renal sodium excretion, and segmental nephron Na+-K+-ATPase activity.
Treated rats with intraperitoneal furosemide (10 mg / 100 g / 24 h) for 7 days.
Maintained a second group of rats on an oral sodium load for 12 days.
Measured glomerular filtration rate (GFR), urinary sodium excretion (UNaV), net sodium reabsorption (NAR), and microdissected nephron segment Na+-K+-ATPase activity.
In furosemide-treated rats, GFR increased from 0.61 ± 0.03 to 0.83 ± 0.06 ml/min (P < 0.01), UNaV increased from 904 ± 71 to 1,402 ± 85 µeq/day (P < 0.001), and net NAR increased from 87.5 ± 3.7 to 116.7 ± 9.0 µeq/min (P < 0.01).
Furosemide increased Na+-K+-ATPase activity in the distal convoluted tubule (from 48.5 ± 1.2 to 75.3 ± 0.7 × 10⁻¹¹ mol·mm⁻¹·min⁻¹, P < 0.001) and cortical collecting duct (from 18.6 ± 0.7 to 27.1 ± 2.7 × 10⁻¹¹ mol·mm⁻¹·min⁻¹, P < 0.02), without changes in proximal or loop segments.
In sodium-loaded rats, GFR increased from 0.61 ± 0.04 to 0.86 ± 0.03 ml/min (P < 0.001), UNaV rose from 1,064 ± 118 to 18,532 ± 2,045 µeq/day (P < 0.001), and Na+-K+-ATPase activity rose selectively in the medullary thick ascending limb from 40.3 ± 1.4 to 56.2 ± 2.11 × 10⁻¹¹ mol·mm⁻¹·min⁻¹ (P < 0.001).

Cite This Study

Scherzer et al. (1987) studied this question.

synapsesocial.com/papers/6a7f5aaac47bc9bb3efbecf3 https://doi.org/10.1152/ajprenal.1987.252.5.f910

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Implication

Animal experiment reveals enhanced filtration and distal tubular Na+-K+-ATPase activity following chronic furosemide administration in rats, indicating compensatory distal sodium handling.

Enhanced glomerular filtration and Na+-K+-ATPase with furosemide administration

Discussion

Member takes

Implication

Key Points

Cite This Study

Enhanced glomerular filtration and Na+-K+-ATPase with furosemide administration

Discussion

Member takes

Implication

Key Points

Cite This Study

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