What question did this study set out to answer?

To determine the long-term hemodynamic and structural renal consequences of sustained furosemide administration and assess whether angiotensin II receptor blockade mitigates these effects.

August 1, 1998AJP Renal PhysiologyOpen Access

Chronic administration of furosemide augments renal weight and glomerular capillary pressure in normal rats

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Why the study?

Does chronic furosemide administration alter renal weight and glomerular capillary pressure in male Munich-Wistar rats?

Population

Male Munich-Wistar rats

Comparison

Daily furosemide or furosemide plus losartan for… vs No therapy (control)

Design

Preclinical

Follow-up

6-8 weeks

Authors

PLPascale H. LaneRoyal Free London NHS Foundation Trust LTL. TylerMedtronic (United States)PSPaul G. SchmitzAvon (United States)

Discussion

Member takes

Implication

Chronic furosemide may drive AT1-mediated renal hypertrophy in rats; leaves open relevance to human diuretic therapy.

Key Points

To determine the long-term hemodynamic and structural renal consequences of sustained furosemide administration and assess whether angiotensin II receptor blockade mitigates these effects.
Assigned male Munich-Wistar rats to 6–8 weeks of daily furosemide (40 mg/day), furosemide plus the AT1 receptor antagonist losartan (5 mg/day), or an untreated control group.
Conducted in vivo glomerular micropuncture experiments to assess intrarenal hemodynamics and measured total renal weight.
Furosemide alone significantly increased renal weight (1.23 ± 0.7 g) compared with control (1.00 ± 0.06 g) and furosemide plus losartan (0.97 ± 0.01 g).
Glomerular capillary hydraulic pressure rose in furosemide-treated rats (52.1 ± 1.5 mmHg) relative to controls (43.7 ± 1.5 mmHg) and losartan-cotreated rats (41.3 ± 1.7 mmHg).
Furosemide increased efferent arteriolar resistance and filtration fraction, but co-administration of losartan markedly attenuated these hemodynamic shifts.

Structured PICO

Does chronic furosemide administration alter renal weight and glomerular capillary pressure in male Munich-Wistar rats?

Population

Male Munich-Wistar rats

Intervention

Daily furosemide (40 mg/day) or furosemide plus losartan (5 mg/day) for 6-8 weeks

Comparator

No therapy (control)

Outcome

Renal weight and glomerular capillary hydraulic pressure (PGC)surrogate

Chronic furosemide administration in normal rats augments renal growth and glomerular capillary pressure, an effect that is completely arrested by the AT1 receptor antagonist losartan.

Cite This Study

Lane et al. (1998) studied this question.

synapsesocial.com/papers/6a81f4e1ac3bbfe76d61014a https://doi.org/10.1152/ajprenal.1998.275.2.f230

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Chronic administration of furosemide augments renal weight and glomerular capillary pressure in normal rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Chronic administration of furosemide augments renal weight and glomerular capillary pressure in normal rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider