Why the study?
Does acute administration of furosemide reduce glomerular filtration rate in subjects with diastolic dysfunction compared to healthy volunteers?
Population
16 subjects total: 8 healthy volunteers and 8 subjects with documented diastolic dysfunction.
Comparison
Furosemide 20 mg orally and 20 mg intravenously… vs Baseline GFR measurement without furosemide, and…
Design
Cohort
Follow-up
immediately after administration
Authors
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Acute furosemide may reduce GFR more in diastolic dysfunction; hypothesis-generating and requires prospective validation.
Does acute administration of furosemide reduce glomerular filtration rate in subjects with diastolic dysfunction compared to healthy volunteers?
Acute administration of furosemide significantly reduces glomerular filtration rate, with a potential for a greater decline in patients with diastolic dysfunction compared to healthy individuals.
Trivedi et al. (2007) studied this question.
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