Key result
Pretreatment with the B2-receptor antagonist FR173657 significantly inhibited furosemide-induced natriuresis by 58.6% in saline-infused rats and 22.4% in hypotonic saline-loading rats.
Population
Rats (anesthetized infused with physiological saline, and hypotonic saline-loading rats)
Comparison
Furosemide with or without B2-receptor… vs Control (furosemide alone or saline alone)
Design
Preclinical
Follow-up
8 h (for metabolic cage collection)
Authors
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Hypothesis-generating in rats; leaves open translation to human diuretic therapy or heart failure management.
Furosemide induces natriuresis partly through augmentation of the renal kallikrein-kinin system in rats.
Fujita et al. (2000) studied Furosemide-induced natriuresis. FR173657 (B2-receptor antagonist) vs. Furosemide alone was evaluated on Furosemide-induced natriuresis (urinary sodium excretion). Pretreatment with the B2-receptor antagonist FR173657 significantly inhibited furosemide-induced natriuresis by 58.6% in saline-infused rats and 22.4% in hypotonic saline-loading rats.
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