What question did this study set out to answer?

To determine whether chronically elevated sodium delivery and uptake stimulate the transport capacity of the distal nephron.

December 1, 1988AJP Renal Physiology

Adaptation of distal tubule and collecting duct to increased Na delivery. II. Na+ and K+ transport

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Authors

BSBruce A. StantonDartmouth College BKBrigitte KaisslingUniversity of Zurich

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Implication

Controlled animal study demonstrates increased sodium uptake enhances distal tubule transport capacity in rats, indicating structural adaptation independent of aldosterone.

Key Points

To determine whether chronically elevated sodium delivery and uptake stimulate the transport capacity of the distal nephron.
Administered furosemide (12 mg/day) or saline vehicle continuously via osmotic minipump for 6 days to adrenalectomized rats.
Maintained constant hormone levels using replacement aldosterone (0.5 µg/100 g/day) and dexamethasone (1.2 µg/100 g/day), preventing volume depletion with a salt drinking solution.
Measured sodium and potassium transport rates in distal tubules using in vivo microperfusion 12 hours after withdrawing furosemide.
Distal tubule sodium absorption increased more than fourfold, rising from 71.7 to 316.7 pmol·min⁻¹·mm⁻¹.
Potassium secretion rose from 30.7 to 73.7 pmol·min⁻¹·mm⁻¹.
Functional transport gains were accompanied by expansion of cell and mitochondrial volumes and extensive proliferation of basolateral membranes in distal tubule cells.

Cite This Study

Stanton et al. (1988) studied this question.

synapsesocial.com/papers/6a6f3f705d37378ac1dc52de https://doi.org/10.1152/ajprenal.1988.255.6.f1269

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Implication

Controlled animal study demonstrates increased sodium uptake enhances distal tubule transport capacity in rats, indicating structural adaptation independent of aldosterone.

Adaptation of distal tubule and collecting duct to increased Na delivery. II. Na+ and K+ transport

Discussion

Member takes

Implication

Key Points

Cite This Study

Adaptation of distal tubule and collecting duct to increased Na delivery. II. Na+ and K+ transport

Discussion

Member takes

Implication

Key Points

Cite This Study

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