October 1, 1975Circulation ResearchOpen Access

Control of renin secretion in the dog. Effects of furosemide on the vascular and macula densa receptors.

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Population

Anesthetized dogs, including models with nonfiltering kidneys and intact filtering kidneys

Comparison

Furosemide 5 mg/kg vs Baseline conditions, prior dilation with…

Design

Preclinical

Authors

WCW CorsiniMichigan State University JHJerry B. HookDartmouth College MBM. D. BailiePfizer (United States)

Discussion

Member takes

Implication

Hypothesis-generating for loop diuretic renin effects in canines; leaves open translation to human cardiorenal therapy.

Structured PICO

Population

Anesthetized dogs, including models with nonfiltering kidneys (2.5 hours of renal ischemia combined with ureteral ligation) and intact filtering kidneys

Intervention

Furosemide 5 mg/kg

Comparator

Baseline conditions, prior dilation with acetylcholine or papaverine, and infusion of d,l-propranolol

Outcome

Renin secretionsurrogate

Furosemide stimulates renin secretion via both macula densa and baroreceptor mechanisms in a canine model.

Cite This Study

Corsini et al. (1975) studied this question.

synapsesocial.com/papers/6a7de90ea7c6153d1433a012 https://doi.org/10.1161/01.res.37.4.464

View Full Paper

Ask AI

Bookmark

Control of renin secretion in the dog. Effects of furosemide on the vascular and macula densa receptors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Control of renin secretion in the dog. Effects of furosemide on the vascular and macula densa receptors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider