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July 1, 1995Hypertension

Effects of Furosemide and Verapamil on the NaCl Dependency of Macula Densa–Mediated Renin Secretion

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Population

Perfused specimens of the juxtaglomerular apparatus microdissected from rabbit kidneys

Comparison

Furosemide and Verapamil vs Varying macula densa NaCl concentrations without…

Design

Preclinical

Authors

XHXiao-Rui HeUniversity of Tennessee Health Science CenterSGSuzanne GreenbergMichigan Department of Health and Human ServicesJSJürgen SchnermannNational Institutes of Health

Discussion

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Implication

No immediate clinical implications; leaves open translation of NKCC and Ca channel roles in renin secretion to human disease.

Structured PICO

P
Population
Perfused specimens of the juxtaglomerular apparatus microdissected from rabbit kidneys
I
Intervention
Furosemide (50 mumol/L added to luminal fluid) and Verapamil (1 mumol/L added to superfusate)
C
Comparator
Varying macula densa NaCl concentrations without drugs
O
Outcome
Renin secretionsurrogate

Furosemide and verapamil abolish the NaCl dependency of renin secretion, suggesting Na-2Cl-K cotransport and calcium flux through voltage-gated channels are required for NaCl-dependent renin release.

Cite This Study

He et al. (1995) studied this question.

synapsesocial.com/papers/6a81f413d363fd3c954cd365https://doi.org/10.1161/01.hyp.26.1.137
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin release from isolated juxtaglomerular apparatus depends on macula densa chloride transport1991 · 179 citations
  2. 2Role of the macula densa in renin release.1985 · 71 citations
  3. 3Characterization of the macula densa stimulus for renin secretion1990 · 31 citations
  4. 4Macula Densa Control of Renin Secretion and Glomerular Vascular Tone: Evidence for Common Cellular Mechanisms1986 · 43 citations
  5. 5Direct Demonstration of Macula Densa-Mediated Renin Secretion1987 · 216 citations