Hemodynamic Effects of Isoproterenol and Propranolol in Tetralogy of Fallot. : Production and Treatment of Anoxic Spells

11 children ranging in age from 3 to 14 years studied at cardiac catheterization (tetralogy of Fallot 7 cases, pulmonary stenosis with intact ventricular septum 2 cases, ventricular septal defect 1 case, patent ductus arteriosus 1 case). All patients were sedated with hydroxyzine hydrochloride, secobarbital and pethidine HCl.

Intravenous isoproterenol (0.1mg/20cc in 5% dextrose in water) infused until heart rate increased by 50%, followed by intravenous propranolol 5γ/kg (2mg/20cc in 5% dextrose in water) administered while the action of isoproterenol persisted.

Baseline hemodynamic measurements prior to drug infusion.

Hemodynamic responses including pressure pulses of pulmonary artery, right ventricle, and femoral artery, and arterial oxygen saturation during cardiac catheterization.surrogate