August 1, 1995Journal of Hypertension
Practical relevance of the 24 hours trough: peak ratio of antihypertensive drugs
Design
Review
Authors
Discussion
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Member takes
Implication
Many once-daily ACEIs/CCBs may lack full 24-h BP coverage; leaves open need for trials confirming optimal T:P dosing.
Structured PICO
I
Intervention
Antihypertensive drugs (angiotensin converting enzyme inhibitors or calcium antagonists)
O
Outcome
Trough:peak ratio > 50%surrogate
A literature survey highlights that many once-daily antihypertensive drugs fail to achieve the recommended trough:peak ratio of >50%, emphasizing the need for prospective trials to evaluate 24-hour blood pressure control.
Cite This Study
Faı̈ez Zannad (1995) studied this question.