March 1, 1997Journal of Neurophysiology

Low-Threshold, Persistent Sodium Current in Rat Large Dorsal Root Ganglion Neurons in Culture

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Population

Dorsal root ganglion neurons from adult rats maintained in culture for 1-3 days; specifically large neurons.

Design

Preclinical

Authors

MBMark D. BakerSwansea University HBHugh BostockNational Hospital for Neurology and Neurosurgery

Discussion

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Implication

May shape DRG neuron excitability models in rats; leaves open translation to human sensory or cardiovascular pathophysiology.

Structured PICO

Population

Dorsal root ganglion neurons from adult rats (≥ 200 g) maintained in culture for 1-3 days; specifically large neurons (50-75 microns apparent diameter).

Intervention

Whole cell patch-clamp technique with ion replacement (replacing external Na+ with tetramethylammonium ions, or reducing external Na+ and raising external Ca2+) and tetrodotoxin (TTX) application.

Outcome

Membrane currents (transient Na+ currents and persistent inward currents)surrogate

Large dorsal root ganglion neurons in rats possess a low-threshold, persistent, TTX-sensitive sodium current that likely plays an important role in determining membrane excitability.

Cite This Study

Baker et al. (1997) studied this question.

synapsesocial.com/papers/6a70a2fbe36a167817e274d4 https://doi.org/10.1152/jn.1997.77.3.1503

View Full Paper

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Low-Threshold, Persistent Sodium Current in Rat Large Dorsal Root Ganglion Neurons in Culture

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Low-Threshold, Persistent Sodium Current in Rat Large Dorsal Root Ganglion Neurons in Culture

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider