Population
Normal and scorpion toxin-resistant neuroblastoma cells
Comparison
Scorpion toxin from Leiurus quinquestriatus vs Comparison between normal and resistant cell…
Design
Preclinical
Authors
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Hypothesis-generating for sodium channel toxin resistance; leaves open relevance to human cardiac channels.
Scorpion toxin resistance in neuroblastoma cells is mediated by a specific change in sodium channel properties that increases the apparent KD for the toxin without impairing normal channel function.
Gonoi et al. (1984) studied this question.
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