Why the study?
Does scanning acoustic microscopy (SAM) correlate with clinical measures of arterial stiffness in patients undergoing aortic bypass graft surgery?
Does scanning acoustic microscopy (SAM) correlate with clinical measures of arterial stiffness in patients undergoing aortic bypass graft surgery?
Scanning acoustic microscopy can measure localized acoustic wave speed in aortic biopsies, showing potential correlations with cholesterol and glucose levels but not with whole-organ pulse wave velocity.
No PWV correlation for SAM acoustic speed; leaves open its value for localized stiffness assessment in aortic samples.
This study explores the use of scanning acoustic microscopy (SAM) as a potential tool for characterisation of arterial stiffness using aortic biopsies. SAM data is presented for human tissue collected during aortic bypass graft surgery for multi-vessel coronary artery disease. Acoustic wave speed as determined by SAM was compared to clinical data for the patients namely, pulse wave velocity (PWV), blood pressure, cholesterol and glucose levels. There was no obvious trend relating acoustic wave speed to PWV values, and an inverse relationship was found between systolic and diastolic blood pressure and acoustic wave speed. However, in patients with a higher cholesterol or glucose level, the acoustic wave speed increased. A more detailed investigation is needed to relate SAM data to clinical measurements.
No takes yet. Share an insight, caveat, or question.
Akhtar et al. (2015) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: