April 5, 2010AJP Heart and Circulatory PhysiologyOpen Access

Vulnerable windows define susceptibility to alternans and spatial discordance

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Population

Monolayers of neonatal rat ventricular myocytes and computational simulations using the Shiferaw-Fox canine…

Comparison

Lowered temperatures, decremental pacing, and… vs Physiological temperature, single-step pacing…

Design

Preclinical

Authors

SWSeth H. WeinbergElectrophysiology NMNeha MalhotraUniversity of Illinois Chicago LTLeslie TungElectrophysiology

Discussion

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Implication

Does not support temperature modulation for arrhythmia prevention in patients; leaves open translation of alternans mechanisms to humans.

Structured PICO

Population

Monolayers of neonatal rat ventricular myocytes (NRVMs) and computational simulations using the Shiferaw-Fox canine model

Intervention

Lowered temperatures (room temperature 24-26°C, cold temperature 18-20°C), decremental pacing, and addition of ATP-sensitive K+ channel agonist pinacidil (50 µM); altered Ca2+ cycling and enhanced K+ currents in computational models

Comparator

Physiological temperature (35-37°C), single-step pacing, and control conditions without pinacidil

Outcome

Incidence of electrophysiological alternans (action potential duration and/or Ca2+ transient amplitude), spatial discordance, spiral wave formation, and measurement of alternans vulnerable windows (AVW and AVWD)surrogate

The study defines vulnerable windows based on pacing cycle lengths that strongly correlate with the incidence of electrophysiological alternans, spatial discordance, and spiral wave formation, providing a theoretical and experimental basis for arrhythmogenesis.

Cite This Study

Weinberg et al. (2010) studied this question.

synapsesocial.com/papers/6a70a46a35aa2c282ce1f778 https://doi.org/10.1152/ajpheart.01036.2009

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Vulnerable windows define susceptibility to alternans and spatial discordance

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Vulnerable windows define susceptibility to alternans and spatial discordance

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider