August 26, 2006心電図 = Electrocardiology

Mechanisms of destabilization and early termination of spiral wave reentry in the ventricle by a class III antiarrhythmic agent, nifekalant

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Why the study?

Does nifekalant destabilize and terminate spiral wave reentry in Langendorff-perfused rabbit hearts?

Population

Langendorff-perfused rabbit hearts (n = 21)

Comparison

Nifekalant (0.1 microM) vs Control (without nifekalant)

Design

Preclinical

Authors

MYMasatoshi YamazakiBunkyo University HHHaruo HonjoHealth Promotion Agency HNHarumichi NakagawaNagoya University

Discussion

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Implication

Nifekalant may destabilize reentry in rabbit models; leaves open translation to clinical VT management.

Structured PICO

Does nifekalant destabilize and terminate spiral wave reentry in Langendorff-perfused rabbit hearts?

Population

Langendorff-perfused rabbit hearts (n = 21)

Intervention

Nifekalant (0.1 microM)

Comparator

Control (without nifekalant)

Outcome

Mechanisms of destabilization and early termination of spiral-type reentrant ventricular tachycardia (including VT duration and phase singularity points)surrogate

Nifekalant destabilizes and early terminates spiral wave reentry by limiting the proportion of excitable tissue after modulating repolarization.

Cite This Study

Yamazaki et al. (2006) studied this question.

synapsesocial.com/papers/6a70a54831a3df824328e733 https://doi.org/10.1152/ajpheart.00640.2006

Topics

Ventricular arrhythmias

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Mechanisms of destabilization and early termination of spiral wave reentry in the ventricle by a class III antiarrhythmic agent, nifekalant

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Mechanisms of destabilization and early termination of spiral wave reentry in the ventricle by a class III antiarrhythmic agent, nifekalant

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider