As a build-up to the synthesis of the proposed structure of azaspiracid, both enantiomers of fragments 2, 3, and 4 were synthesized stereoselectively. Piv=pivaloyl, PFP=pentafluorophenyl, Teoc=2-(trimethylsilyl)ethoxycarbonyl, TES=triethylsilyl.
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Nicolaou et al. (2003) studied this question.
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