Why the study?
Accumulating evidence shows that many TRIM proteins are linked to cardiac processes and pathologies, motivating an overview of their roles in cardiac proteostasis, pathophysiology, and therapeutic potential.
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TRIM proteins emerge as cardiovascular regulators; extends mechanistic insights but leaves clinical targeting open.
Ubiquitination is one of the basic mechanisms of cell protein homeostasis and degradation and is accomplished by 3 enzymes, E1, E2, and E3. Tripartite motif-containing proteins (TRIMs) constitute the largest subfamily of RING E3 ligases, with >70 current members in humans and mice. These members are involved in multiple biological processes, including growth, differentiation, and apoptosis as well as disease and tumorigenesis. Accumulating evidence has shown that many TRIM proteins are associated with various cardiac processes and pathologies, such as heart development, signal transduction, protein degradation, autophagy mediation, ion channel regulation, congenital heart disease, and cardiomyopathies. In this review, we provide an overview of the TRIM family and discuss its involvement in the regulation of cardiac proteostasis and pathophysiology and its potential therapeutic implications.
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Zhang et al. (2020) studied this question.
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