Key result
TRIM proteins play an important role in the pathophysiology of vascular diseases by regulating intracellular signaling, apoptosis, autophagy, proliferation, inflammation, and immunity.
Why the study?
Recent studies have revealed the importance of TRIM proteins in the pathophysiology of vascular diseases, prompting a review of their effects and therapeutic potential.
TRIM proteins are emerging as important regulators in the pathophysiology of vascular diseases, offering potential new therapeutic targets.
TRIM proteins emerge as vascular regulators; leaves open therapeutic targeting pending clinical validation.
There are more than 80 different tripartite motifs (TRIM) proteins within the E3 ubiquitin ligase subfamily, including proteins that regulate intracellular signaling, apoptosis, autophagy, proliferation, inflammation, and immunity through the ubiquitination of target proteins. Studies conducted in recent years have unraveled the importance of TRIM proteins in the pathophysiology of vascular diseases. In this review, we describe the effects of TRIM proteins on vascular endothelial cells, smooth muscle cells, heart, and lungs. In particular, we discuss the potential mechanisms by which TRIMs regulate diseases and shed light on the potential therapeutic applications of TRIMs.
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Xinxin Chen (2023) conducted a review in Vascular disease. TRIM proteins was evaluated. TRIM proteins play an important role in the pathophysiology of vascular diseases by regulating intracellular signaling, apoptosis, autophagy, proliferation, inflammation, and immunity.
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