Population
Dictyostelium myosin-II tail fragments and myosin-null Dictyostelium cells
Comparison
Expression of various myosin-II tail fragments… vs Full-length myosin-II or wild-type constructs
Design
Preclinical
Authors
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Defines minimal domains for bipolar thick filament assembly; leaves open whether charge-based regulation applies to cardiac myosin-II in vivo.
The study demonstrates that a globular head limits the size of a bipolar thick filament and that the large-scale charge character of the AD-Cterm region is important for BTF formation in Dictyostelium.
Hostetter et al. (2004) studied this question.
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