Intermolecular versus intramolecular interactions of Dictyostelium myosin: possible regulation by heavy chain phosphorylation.

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Population

Dictyostelium myosin molecules

Design

Preclinical

Authors

Discussion

Limited to Dictyostelium; leaves open whether heavy-chain phosphorylation similarly controls myosin filament assembly in mammalian cardiac muscle.

Population

Dictyostelium myosin molecules

Intervention

Phosphorylation of the heavy chain by Dictyostelium myosin heavy chain kinase

Outcome

Myosin configuration (straight parallel dimers vs folded monomers) and filament assembly

Heavy chain phosphorylation regulates Dictyostelium myosin assembly by promoting a folded monomer configuration that is excluded from filaments.

Pasternak et al. (1989) studied this question.

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Limited to Dictyostelium; leaves open whether heavy-chain phosphorylation similarly controls myosin filament assembly in mammalian cardiac muscle.