Why the study?
Pediatric obesity causes hypertension and left ventricular hypertrophy, but whether tri-ponderal mass index is associated with left ventricular hypertrophy in obese Caucasian children and adolescents was unassessed.
In obese children and adolescents, left ventricular remodeling is associated with the cardio-metabolic risk marker WHR, but not directly with the adiposity index TMI.
TMI may flag LVH risk in obese youth; leaves open its added value over BMI in prospective cohorts.
Background: Pediatric obesity is a global emerging burden for society; among its health-related consequences there are hypertension (HTN) and left ventricular hypertrophy (LVH). Several anthropometric indices have been investigated for the early identification of cardiovascular risk in children. The aim of the present study was to assess whether tri-ponderal mass index (TMI) was associated with LVH in a cohort of obese Caucasian children and adolescents. Methods: In this observational study, 63 obese children and adolescent aged 7-to-16 years were enrolled. During outpatient visits, adiposity, and cardio-metabolic indices (BMI z-score, WHR, TMI, ABSI) were collected. All subjects underwent a 24-hour ambulatory blood pressure monitoring (ABPM) and transthoracic echocardiography. Results: Obese children and adolescents with LVH had significantly higher BMI z-score (p=0.009), WHR (p=0.006) and TMI (p=0.026) compared to children without LVH. WHR was the only index significantly correlated with left ventricular mass index (LVMI) (p 0.017). Conclusion: Left ventricular remodeling is associated with the cardio-metabolic risk marker WHR, but not with the adiposity index TMI among obese children.
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Vizzuso et al. (2023) studied this question.
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