Association Between Adiposity and Left Ventricular Mass in Children With Hypertension
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Key result
Higher baseline body mass index z score was independently associated with a greater increase in left ventricular mass index over 1 year in hypertensive children (b=4.08, P=0.002).
Why the study?
Is adiposity associated with an increase in left ventricular mass index over time in hypertensive children?
Population
49 hypertensive children, mean age 13.8, 59% male, 39% African American, referred to a pediatric nephrology…
Comparison
Adiposity vs Healthy weight children (BMI <85th percentile)
Design
Cohort
Follow-up
average 12.8 months
Authors
Discussion
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Implication
Adiposity may accelerate LVMI progression in hypertensive children beyond BP effects; leaves open whether weight reduction alters remodeling.
Study Design
Type
Cohort (n=49)
Multicenter
No
Structured PICO
Is adiposity associated with an increase in left ventricular mass index over time in hypertensive children?
P
Population
49 hypertensive children aged 3 to 22 years, free of congenital heart disease or advanced chronic kidney disease, followed for 1 year to assess the association between adiposity and left ventricular mass index.
E
Exposure
Adiposity (overweight/obese status defined as BMI ≥85th percentile, and baseline BMI z score)
C
Comparator
Healthy weight children (BMI <85th percentile)
O
Outcome
Change in left ventricular mass index (LVMI) from baseline to 12 months, measured by echocardiographysurrogate
Main Result
Mean Difference: 4.08 (95% CI 1.54–6.61)
p-value: p=0.002
In hypertensive children, adiposity is a stronger independent driver of increasing left ventricular mass index over time than blood pressure itself.
Limitations
- Relatively small sample size
- Observational design unable to infer causality
- Potential selection bias from recruiting at a pediatric nephrology referral clinic
- Majority of children were not fasting at the time of their study visit
- Blood pressure was a controlled variable with a high degree of intraindividual variability
Cite This Study
Brady et al. (2015) conducted a cohort in Hypertension (n=49). Baseline BMI z score vs. Lower BMI z score was evaluated on Change in left ventricular mass index (LVMI) (b=4.08, 95% CI 1.54-6.61, p=0.002). Higher baseline body mass index z score was independently associated with a greater increase in left ventricular mass index over 1 year in hypertensive children (b=4.08, P=0.002).
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