Single‐unit muscle sympathetic nervous activity and its relation to cardiac noradrenaline spillover
Population
22 patients with hypertension (n=6), depression (n=7), and panic disorder (n=9)
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Multiple within-burst firing was associated with doubled cardiac noradrenaline spillover; leaves open its role in cardiac sympathetic drive.
Key Points
- This research investigates the link between muscle sympathetic nerve firing patterns and cardiac noradrenaline release.
- Examined patients with hypertension, depression, and panic disorder (n=22) using single-unit muscle sympathetic nerve recording techniques.
- Utilized cardiac catheterisation and noradrenaline isotope dilution methodology to measure spillover to plasma.
- Participants were categorized based on firing patterns into low and high incidence groups.
- High incidence of spikes correlated with greater firing rates (P <0.0001) and firing probabilities (P <0.0001).
- Cardiac noradrenaline spillover was twice as high in subjects with high incidence of spikes compared to those with low incidence (22.0 ± 4.5 ng min⁻¹ vs. 11.0 ± 1.5 ng min⁻¹, P <0.05).
- No significant difference in whole body noradrenaline spillover was observed between the two firing pattern groups.
Structured PICO
P
Population
22 patients with hypertension (n=6), depression (n=7), and panic disorder (n=9)
O
Outcome
Relationship between single-unit firing patterns and cardiac and whole body noradrenaline spillover to plasmasurrogate
Multiple within-burst firing and increased single-unit firing rates of sympathetic outflow to skeletal muscle are associated with high cardiac noradrenaline spillover.
Cite This Study
Lambert et al. (2011) studied this question.