Simultaneous measurements of cardiac noradrenaline spillover and sympathetic outflow to skeletal muscle in humans.
Why the study?
Do isometric handgrip and mental stress alter muscle sympathetic nerve activity and cardiac noradrenaline spillover compared to rest in healthy subjects?
Population
10 healthy subjects
Comparison
Isometric handgrip at 30% of maximum power and… vs Rest
Design
Other
Authors
Discussion
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Implication
Differential sympathetic responses to handgrip versus mental stress in healthy subjects; leaves open relevance to autonomic dysregulation in cardiovascular disease.
Structured PICO
Do isometric handgrip and mental stress alter muscle sympathetic nerve activity and cardiac noradrenaline spillover compared to rest in healthy subjects?
P
Population
10 healthy subjects
I
Intervention
Isometric handgrip at 30% of maximum power and stress induced by forced mental arithmetic
C
Comparator
Rest
O
Outcome
Muscle sympathetic nerve activity (MSA), intra-arterial blood pressure, and whole-body and cardiac noradrenaline spillover to plasmasurrogate
Handgrip and mental stress elicit different balances of sympathetic outflow to the heart and skeletal muscle in healthy humans.
Cite This Study
Wallin et al. (1992) studied this question.