Direct Impact of Pomegranate Juice and Peel Extracts on Prostate Cancer Progression - Inhibition of Proliferation, Migration, and Colony Formation in Prostate Cancer Cell Lines

Prostate cancer, which affects millions of men worldwide, is a prevalent form of cancer.The risk factors associated with it include age, genetics, and diet.Despite advances in cancer research, the quest for effective treatments and preventive measures against this disease remains an ongoing challenge.Pomegranate, a fruit known for its antioxidant-rich juice and bioactive peel extracts, has been identified as a prospective therapeutic intervention for various health ailments, including cancer.The current study looked at the direct effects of the juice of pomegranates and peel extract on the advancement of prostate cancer.Its ability to suppress the colony formation, motility, and proliferation of prostate cancer cell lines as cancer cells was assessed.The decline in cell survival after an injection of PP extract was measured using the Mean Transit Time (MTT) test to do this.Prostate cancer cells' ability to form colonies and to be inhibited from migrating was also evaluated using the clonogenic assay and wound healing experiment conducted with the help of pomegranate extracts.The results revealed promising inhibitory effects of pomegranate extracts on these key cancer hallmarks, suggesting their potential as complementary therapeutic agents for prostate cancer.