What question did this study set out to answer?

To evaluate the impact of pathological tumor characteristics and surgical extent on postoperative mortality and long-term prognosis in patients with stomach carcinoma.

December 1, 1970British journal of surgery

Pathology and prognosis of carcinoma of the stomach

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Authors

PHP R HawleyUniversity of Chester PWPeter WesterholmUppsala University BMB C MorsonSt Mark's Hospital

Discussion

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Implication

Cohort study reveals major pathological determinants of survival in gastric carcinoma, showing lymph node involvement and immune infiltration dictate prognosis.

Key Points

To evaluate the impact of pathological tumor characteristics and surgical extent on postoperative mortality and long-term prognosis in patients with stomach carcinoma.
Retrospective cohort analysis of 205 patients who underwent partial (n = 116, 61%) or total (n = 74, 39%) gastrectomy for stomach carcinoma between 1951 and 1955.
Evaluation of postoperative mortality, 5-year and 10-year crude survival rates across tumor sites, histological differentiation, immune infiltration, and regional lymph-node involvement.
Overall postoperative mortality was 25% (higher in total than partial gastrectomy), with crude survival rates of 19.4% at 5 years and 11.4% at 10 years.
Regional lymph-node involvement strongly influenced prognosis: 5-year survival reached 40% in node-negative disease versus 11% when nodes were involved.
Poorly differentiated tumors, cardia location, and linitis plastica (0% 5-year survival) showed unfavorable prognosis, while marked lymphocytic and plasma-cell infiltration conferred superior survival (5 of 7 patients survived >5 years).

Cite This Study

Hawley et al. (1970) studied this question.

synapsesocial.com/papers/6a70a9d0660549caf2c548ff https://doi.org/10.1002/bjs.1800571202

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December 1, 1970British journal of surgery

Pathology and prognosis of carcinoma of the stomach

View Full Paper

Ask AI

Bookmark

Authors

PHP R HawleyUniversity of Chester PWPeter WesterholmUppsala University BMB C MorsonSt Mark's Hospital

Discussion

Member takes

Implication

Cohort study reveals major pathological determinants of survival in gastric carcinoma, showing lymph node involvement and immune infiltration dictate prognosis.

Key Points

To evaluate the impact of pathological tumor characteristics and surgical extent on postoperative mortality and long-term prognosis in patients with stomach carcinoma.
Retrospective cohort analysis of 205 patients who underwent partial (n = 116, 61%) or total (n = 74, 39%) gastrectomy for stomach carcinoma between 1951 and 1955.
Evaluation of postoperative mortality, 5-year and 10-year crude survival rates across tumor sites, histological differentiation, immune infiltration, and regional lymph-node involvement.
Overall postoperative mortality was 25% (higher in total than partial gastrectomy), with crude survival rates of 19.4% at 5 years and 11.4% at 10 years.
Regional lymph-node involvement strongly influenced prognosis: 5-year survival reached 40% in node-negative disease versus 11% when nodes were involved.
Poorly differentiated tumors, cardia location, and linitis plastica (0% 5-year survival) showed unfavorable prognosis, while marked lymphocytic and plasma-cell infiltration conferred superior survival (5 of 7 patients survived >5 years).

Cite This Study

Hawley et al. (1970) studied this question.

synapsesocial.com/papers/6a70a9d0660549caf2c548ff https://doi.org/10.1002/bjs.1800571202

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