Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 3, 2020BMC Medical GenomicsOpen Access

Weighted correlation network bioinformatics uncovers a key molecular biosignature driving the left-sided heart failure

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Left-sided heart failure is a key prognostic factor, but the relative molecular mechanisms underlying it remain unknown.

Population

319 samples in GSE57345 dataset with validation based on GSE1869 dataset

Design

Bioinformatics and weighted gene correlation network analysis (WGCNA) study

Authors

JZJiamin ZhouQingdao UniversityWZWei ZhangShanghai Jiao Tong UniversityCWChunying WeiNanchang University

Discussion

Loading...

Member takes

Implication

Pivotal genes and modules in left-sided HF are hypothesis-generating; prospective validation needed before prognostic use.

Structured PICO

P
Population
319 samples from the GSE57345 dataset (including 96 patients with ischemic heart disease and 84 patients with dilated cardiomyopathy) and validation samples from the GSE1869 dataset (including 6 non-HF patients and patients with HF after AMI).
O
Outcome
Identification of significant gene modules, hub genes, and transcription factors associated with left-sided heart failure, ischemic heart disease, and dilated cardiomyopathy.surrogate

Bioinformatics analysis identified OGN, HTRA1, and MXRA5 as key genes and potential biomarkers associated with the progression of left-sided heart failure.

Cite This Study

Zhou et al. (2020) studied this question.

synapsesocial.com/papers/6a70ab2826a7f98052dd24cehttps://doi.org/10.1186/s12920-020-00750-9

Topics

Heart failureHFrEF treatment
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CRISPLD1: a novel conserved target in the transition to human heart failure2020 · 17 citations
  2. 2Early Diagnosis of Myocardial Infarction with Sensitive Cardiac Troponin Assays2019 · 133 citations
  3. 3Troponin I Levels and Postoperative Myocardial Infarction following Renal Transplantation2012 · 17 citations
  4. 4Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity2018 · 77 citations
  5. 5Early blood transcriptomic signature predicts patients’ outcome after out-of-hospital cardiac arrest2019 · 14 citations