Why the study?
Data are lacking on DNA methylation in heart failure specifically focusing on patients with severe multi-vessel coronary artery disease.
Peripheral blood DNA methylation profiling can identify distinct epigenetic patterns separating severe coronary artery disease patients with and without heart failure, highlighting potential novel biomarkers such as HDAC9, JARID2, GREM1, and PDSS2.
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DNA methylation patterns may distinguish ischemic HF phenotypes; hypothesis-generating pilot data requiring prospective validation before clinical consideration.
Bain et al. (2020) studied this question.
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