Why the study?
Does a combined surgical approach of carotid endarterectomy and cardiac procedures prevent perioperative stroke in patients with coexisting significant cardiac and carotid disease?
Does a combined surgical approach of carotid endarterectomy and cardiac procedures prevent perioperative stroke in patients with coexisting significant cardiac and carotid disease?
Combined carotid endarterectomy immediately before cardiopulmonary bypass is a safe approach to prevent perioperative stroke in patients with severe coexisting cardiac and carotid disease.
Suggests combined CEA-cardiac surgery may be feasible with low stroke risk; hypothesis-generating and should not change practice without RCTs.
Severe cerebrovascular complications following cardiac surgical procedures remain a major concern, particularly in patients with significant carotid atherosclerotic involvement (14% of perioperative stroke). Operative mortality for carotid operations in patients with documented Coronary Artery Disease (CAD) may be as high as 20%. Seventy patients underwent combined operations (unilateral carotid stenosis > 70%, unilateral stenosis > 50% with ulcerated plaque or bilateral stenoses > 50%; and this also included patients with unilateral occlusion). Cardiac procedures were 69 coronary artery bypass grafts, four left ventricular aneurysmectomies, three aortic valve replacements and surgery on two mitral valves. Seven perioperative deaths occurred, which were all caused by cardiac events. There were no perioperative strokes. Carotid endarterectomy immediately before cardiopulmonary bypass is a safe and expeditious approach to coexisting significant cardiac and carotid disease. In our experience, technical details in monitoring and minimizing cerebral ischemia are possibly more crucial in these severe vasculopathic patients. Moreover, it is probably advantageous from an economic standpoint compared with other therapeutic treatments.
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Donatelli et al. (1998) studied this question.
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