Why the study?
Does the LLHPT assay provide comparable precision to the XaI assay for measuring heparin concentration in whole blood and plasma?
Population
In vitro specimens of plasma and whole blood with added unfractionated heparin
Comparison
Low-level heparin protamine titration assay vs Factor Xa inhibition (XaI) assay
Design
Preclinical
Authors
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LLHPT may enable rapid heparin monitoring comparable to XaI in vitro; animal data leave clinical adoption unproven.
Does the LLHPT assay provide comparable precision to the XaI assay for measuring heparin concentration in whole blood and plasma?
The LLHPT assay provides rapid, precise in vitro monitoring of heparin concentration comparable to the XaI assay, suggesting potential utility for bedside monitoring.
Schlueter et al. (1997) studied this question.
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