Key result
Sublingual nifedipine alters acute haemodynamics in patients with chronic heart failure.
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Nifedipine, a calcium antagonist with strong vasodilatating effects, has been successfully used in the treatment of angina pectoris. To investigate if it can be used as a vasodilator in patients with congestive heart failure, nifedipine 20 mg was administered sublingually to 11 patients with chronic heart failure. The clinical diagnosis was congestive cardiomyopathy in 10 and severe mitral regurgitation in one patient. All patients were studied haemodynamically and in 10 of them an angiographic study was also performed.
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Klugmann et al. (1980) studied Chronic heart failure (n=11). Nifedipine was evaluated on Haemodynamic and angiographic effects.
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