Why the study?
Does dimethylamiloride prevent mechanical and energetic disorders after rapid correction of acidosis in excised canine hearts?
Population
13 excised cross-circulated canine hearts
Comparison
Dimethylamiloride (a selective Na-H+ exchange… vs Rapid correction of acidosis without…
Design
Preclinical
Authors
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Dimethylamiloride may avert post-correction myocardial depression in canine models; leaves open whether Na+/H+ exchange inhibition benefits human hearts.
Does dimethylamiloride prevent mechanical and energetic disorders after rapid correction of acidosis in excised canine hearts?
Rapid recovery of pH paradoxically depresses myocardial contractility and increases the oxygen cost of contractility through activation of the Na(+)-H+ exchange system, which can be prevented by dimethylamiloride.
Hata et al. (1994) studied this question.
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