Termination of Cardiac Ca ²⁺ Sparks
Population
Permeabilized ventricular cardiomyocytes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports fixed depletion threshold for reliable Ca2+ release termination; leaves open translation from animal models to clinical arrhythmias.
Structured PICO
P
Population
Permeabilized ventricular cardiomyocytes
I
Intervention
Variation of sarcoplasmic reticulum (SR) Ca2+ loads and release fluxes
O
Outcome
Regulation of SR Ca2+ release termination (Ca2+ sparks and Ca2+ blinks)surrogate
Reliable sarcoplasmic reticulum Ca2+ release termination depends on tight ryanodine receptor regulation by intra-SR free Ca2+ at a fixed depletion threshold.
Cite This Study
Zima et al. (2008) studied this question.