The study demonstrates that a single Kv1.1 subunit confers high affinity for dendrotoxin k, while the overall electrophysiological properties of the channel depend on the relative ratio of Kv1.1 to Kv1.2, providing insights into episodic ataxia I.
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Does not alter ataxia management; leaves open how Kv1.1 stoichiometry shapes native channel function in vivo.
Akhtar et al. (2002) studied this question.
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