Statin therapy improves brachial artery vasodilator function in patients with Type 1 diabetes and microalbuminuria
Why the study?
Does atorvastatin improve brachial artery vasodilator function in patients with Type 1 diabetes and microalbuminuria?
Structured PICO
Does atorvastatin improve brachial artery vasodilator function in patients with Type 1 diabetes and microalbuminuria?
P
Population
16 Type 1 diabetes mellitus patients with microalbuminuria
I
Intervention
Atorvastatin 40 mg/day for 6 weeks
C
Comparator
Placebo for 6 weeks (crossover design with 4-week washout)
O
Outcome
Brachial artery, endothelium-dependent, flow-mediated dilatation (FMD) and endothelium-independent, glyceryl trinitrate-mediated dilatation (GTNMD)surrogate
Atorvastatin 40 mg/day significantly improves endothelium-dependent and independent vasodilator function in patients with Type 1 diabetes and microalbuminuria, likely via pleiotropic effects.
Authors
Discussion
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Implication
Supports atorvastatin for vascular function in T1DM with microalbuminuria; extends RCT evidence for statins in Type 1 diabetes.
Cite This Study
Dogra et al. (2005) studied this question.