Why the study?
Does losartan compared to atenolol reduce cardiovascular events across quartiles of baseline pulse pressure in patients with hypertension and left ventricular hypertrophy?
Population
Patients with hypertension and left ventricular hypertrophy (from the LIFE study)
Comparison
Losartan vs Atenolol
Design
Cohort
Authors
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High pulse pressure was associated with excess events on atenolol but not losartan in hypertensive LVH; hypothesis-generating for differential effects.
Does losartan compared to atenolol reduce cardiovascular events across quartiles of baseline pulse pressure in patients with hypertension and left ventricular hypertrophy?
Losartan appears to attenuate the increased cardiovascular risk associated with high pulse pressure better than atenolol in patients with hypertension and left ventricular hypertrophy.
Fyhrquist et al. (2005) studied this question.
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