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October 11, 2008AJP Heart and Circulatory Physiology

Subject-specific profiles of QT/RR hysteresis

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Population

40 healthy subjects (18 females; mean age, 30.4+/-8.1 yr)

Design

Cross-sectional

Authors

MMMarek MalíkElectrophysiologyKHKaterina HnatkovaElectrophysiologyTNTomáš NovotnýPoole Hospital

Discussion

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Implication

Supports individualized QT/RR correction in repolarization studies; leaves open prospective validation for clinical use.

Structured PICO

P
Population
40 healthy subjects (18 females; mean age, 30.4+/-8.1 yr)
I
Intervention
3 separate daytime (>13 h) 12-lead electrocardiograms (ECG) per subject to measure QT/RR hysteresis
O
Outcome
QT/RR hysteresis characterized by lambda parameters of exponential decay models, comparing intrasubject versus intersubject variabilitysurrogate

QT/RR hysteresis is a highly individual physiological process with intrasubject stability, and its individual correction may substantially improve cardiac repolarization studies.

Cite This Study

Malík et al. (2008) studied this question.

synapsesocial.com/papers/6a70b06f31a3df824328f243https://doi.org/10.1152/ajpheart.00625.2008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Impact of QT Lag Compensation on Dynamic Assessment of Ventricular Repolarization: Reproducibility and the Impact of Lead Selection2001 · 23 citations
  2. 2Hysteresis of the ventricular paced QT interval in response to abrupt changes in pacing rate1988 · 199 citations
  3. 3Sex-Selective QT Prolongation During Rapid Eye Movement Sleep2002 · 41 citations
  4. 4Analyses of Dynamic Beat‐to‐Beat QT–TQ Interval (ECG Restitution) Changes in Humans under Normal Sinus Rhythm and Prior to an Event of Torsades de Pointes during QT Prolongation Caused by Sotalol2007 · 41 citations
  5. 5Individual Patterns of Dynamic QT/RR Relationship in Survivors of Acute Myocardial Infarction and Their Relationship to Antiarrhythmic Efficacy of Amiodarone2004 · 38 citations