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March 1, 2002HeartOpen Access

Relation between QT and RR intervals is highly individual among healthy subjects: implications for heart rate correction of the QT interval

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Population

50 healthy volunteers (25 women, mean age 33.6 (9.5) years, range 19-59 years)

Design

Cross-sectional

Follow-up

24 hours

Authors

MMMarek Malík

Discussion

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Overview

Substantial QT/RR variability supports individualized correction in research; leaves routine clinical adoption open pending prospective data.

Structured PICO

P
Population
50 healthy volunteers (25 women, mean age 33.6 (9.5) years, range 19-59 years)
I
Intervention
Serial 12 lead electrocardiographic monitoring over 24 hours with a 10 second ECG obtained every two minutes
O
Outcome
QT/RR relation modeled using six generic regressions (linear, hyperbolic, parabolic) to test parallelism and identity of regression lines in separate subjectssurrogate

The QT/RR relationship exhibits substantial intersubject variability, indicating that universal heart rate correction formulas are imprecise and individual QT/RR relations should be used for detailed studies.

Cite This Study

Marek Malík (2002) studied this question.

synapsesocial.com/papers/6a7d6fb6ade38b7dc346e4a1https://doi.org/10.1136/heart.87.3.220
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Steady‐State versus Non‐Steady‐State QT‐RR Relationships in 24‐hour Holter Recordings2000 · 34 citations
  2. 2If Dr. Bazett Had Had a Computer…1996 · 33 citations
  3. 3Rate dependence of sotalol-induced prolongation of ventricular repolarization during exercise in humans.1991 · 70 citations
  4. 4Hysteresis of the ventricular paced QT interval in response to abrupt changes in pacing rate1988 · 199 citations