Key result
The extent of circadian variation in QTc depends highly on the heart rate correction formula used, with under- and overcorrection resulting in significant misestimation of the circadian pattern.
Why the study?
Does the choice of heart rate correction model impact the assessment of circadian variation in the QTc interval in healthy subjects?
Population
53 healthy subjects (25 men aged 27 +/- 7 years and 28 women aged 27 +/- 9 years)
Comparison
Four common heart rate correction models applied… vs Individually optimized heart rate correction model
Design
Cross-sectional
Follow-up
24 hours
Authors
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Clinicians risk misestimating QTc diurnal changes with standard formulas; leaves open role of individualized correction in repolarization studies.
Observational (n=53)
Does the choice of heart rate correction model impact the assessment of circadian variation in the QTc interval in healthy subjects?
The extent of circadian variation in QTc depends highly on the heart rate correction formula used, highlighting the need for individualized correction to accurately assess diurnal variations.
Smetana et al. (2003) conducted an observational in Healthy subjects (n=53). Common heart rate correction models vs. Individually optimized heart rate correction model was evaluated on Diurnal variations in QTc. The extent of circadian variation in QTc depends highly on the heart rate correction formula used, with under- and overcorrection resulting in significant misestimation of the circadian pattern.
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