Highlights the concept of diabetic cardiomyopathy as a distinct cause of heart failure in diabetic patients without significant coronary artery disease.
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Supports diabetic cardiomyopathy evaluation in women with HF without CAD; leaves open prospective trials to confirm independence from CAD.
Heart failure seems to occur in adult-onset diabetics with a greater frequency than in the nondiabetic population, particularly in women. A number of such patients do not have significant occlusive disease of the major coronary arteries, or convincing small-vessel disease. A subclinical abnormality of myocardium in experimental diabetes and asymptomatic human diabetics supports the concept of a diabetic cardiomyopathy.
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Timothy J. Regan (1983) studied this question.
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