April 15, 2020Open Access

Younger age of patients with myocardial infarction correlates with higher number of relatives with history of premature atherosclerosis

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Why the study?

Premature coronary artery disease is a pressing global issue, and family history appears to be one of the most important risk factors in young patients with myocardial infarction.

Does a family history of premature cardiovascular disease correlate with a younger age of first myocardial infarction?

Population

240 MI patients aged <50 years, 240 MI patients aged ≥50 years, and 240 healthy controls

Comparison

MI patients <50 years vs MI patients ≥50 years vs young healthy controls

Design

Case-control study

Authors

MAMichał AmbroziakCentrum Medyczne Kształcenia Podyplomowego KNKatarzyna Niewczas-WieprzowskaGrochowski Hospital AMAgnieszka MaickaGrochowski Hospital

Discussion

Member takes

Implication

Family history of premature CVD may aid risk assessment in young MI patients; leaves open its added value beyond conventional factors in larger cohorts.

Structured PICO

Does a family history of premature cardiovascular disease correlate with a younger age of first myocardial infarction?

Population

720 participants from Poland, including 240 patients with first-episode myocardial infarction (MI) aged <50 years (mean age 43.5, 78.3% male), 240 patients with first-episode MI aged ≥50 years (mean age 65.9, 63.3% male), and 240 healthy controls aged <50 years without a history of CAD (mean age 43.2, 57.1% male).

Intervention

Family history of premature cardiovascular disease (MI or ischemic stroke in men aged <55 and in women aged <65), including first- and second-degree relatives.

Comparator

Patients without a family history of premature cardiovascular disease, or older patients (MI ≥50 years) and healthy controls (no-MI <50 years).

Outcome

Prevalence of family history of premature MI/ischemic stroke and the percentage of patients with ≥2 affected relatives.

A family history of premature atherosclerosis, particularly involving multiple first- and second-degree relatives, is strongly associated with an earlier onset of myocardial infarction.

Limitations

Relatively small number of patients, making findings difficult to apply to a larger, more diverse population
High homogeneity of the groups (limited to the Polish population of Caucasian ethnicity)
Control group of young healthy blood donors may be more educated and health-conscious than the general population

Cite This Study

Ambroziak et al. (2020) studied this question.

synapsesocial.com/papers/6a70b69f35aa2c282ce207c6 https://doi.org/10.21203/rs.3.rs-20951/v1

View Full Paper

Ask AI

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Implication

Family history of premature CVD may aid risk assessment in young MI patients; leaves open its added value beyond conventional factors in larger cohorts.

Younger age of patients with myocardial infarction correlates with higher number of relatives with history of premature atherosclerosis

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Younger age of patients with myocardial infarction correlates with higher number of relatives with history of premature atherosclerosis

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider