Why the study?
Does a family history of MI increase the risk of acute MI?
Population
2,022 subjects (916 cases of newly diagnosed MI and 1,106 hospital controls) in Italy.
Comparison
Family history of MI in first-degree relatives vs No family history of MI in first-degree relatives
Design
Case-control
Authors
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Family history of MI may refine risk stratification; leaves open its incremental predictive value beyond traditional factors in prospective cohorts.
Does a family history of MI increase the risk of acute MI?
A family history of MI is an independent risk factor for acute MI, with the risk increasing based on the number of affected relatives and interacting multiplicatively with other major risk factors.
Roncaglioni et al. (1992) studied this question.
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