Key result
Family history of coronary heart disease increased myocardial infarction risk (OR 2.0, 95% CI 1.6-2.6 for men; OR 2.1, 95% CI 1.5-3.0 for women) and interacted synergistically with other risk factors.
Why the study?
Does a family history of coronary heart disease increase the risk of myocardial infarction in adults aged 45 to 70 years?
Case-Control
Does a family history of coronary heart disease increase the risk of myocardial infarction in adults aged 45 to 70 years?
Effect estimate: OR 2.0 (95% CI 1.6-2.6)
Family history of coronary heart disease is a strong risk factor for myocardial infarction and has synergistic effects with other risk factors such as smoking, high LDL/HDL ratio, and diabetes.
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May aid MI risk stratification in adults 45-70; extends synergistic interaction evidence but remains hypothesis-generating.
Leander et al. (2001) conducted a case-control in Myocardial infarction. Family history of coronary heart disease vs. No family history of coronary heart disease was evaluated on Myocardial infarction (OR 2.0, 95% CI 1.6-2.6). Family history of coronary heart disease increased myocardial infarction risk (OR 2.0, 95% CI 1.6-2.6 for men; OR 2.1, 95% CI 1.5-3.0 for women) and interacted synergistically with other risk factors.
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