Why the study?
Is family history of CHD associated with increased CHD prevalence and adverse risk factors in an Afrikaner community?
Population
5,895 adults (2,722 men and 3,173 women) aged 25-64 years from an Afrikaner community
Comparison
Family history of coronary heart disease (CHD) vs No family history of CHD
Design
Cross-sectional
Authors
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May support family history-informed risk stratification in similar populations; leaves open whether lipid effects on MI differ by genetic predisposition.
Is family history of CHD associated with increased CHD prevalence and adverse risk factors in an Afrikaner community?
Family history of CHD interacts with cholesterol levels to increase the risk of myocardial infarction, suggesting that high cholesterol is particularly atherogenic in those with a genetic predisposition.
Rossouw et al. (1991) studied this question.
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